Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population
Joint Authors
Zhang, Guohong
Chen, Guangcan
Xu, Muming
Chen, Jingyao
Hong, Liangli
Lin, Wenting
Zhao, Shukun
Dan, Guo
Liu, Shuhui
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The incidence of gastric cardia cancer (GCC) is high in China.
However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear.
Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC).
We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients.
Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa (n=11), gastric cardia inflammation (n=87), and GCC (n=103).
We included 84 patients with EC and 99 with GCC.
GCC tissue was more poorly differentiated than EC tissue and more invasive, with more histomorphologic variation.
Lymph node metastasis was more frequent in GCC than in EC.
The Helicobacter pylori infection rate was higher but not significantly with GCC than EC.
Survival was shorter with lymph node metastasis.
We found a statistically significant trend for progressive increase of TLR4 expression from normal mucosa to inflammation in GCC.
GCC in this high-risk area displays clinicopathologic characteristics different from those of EC and different from those of gastroesophageal junction carcinomas in other countries, although this was not analyzed statistically.
Increased TLR4 expression in gastric cardia lesions may be associated with GCC tumorigenesis.
American Psychological Association (APA)
Chen, Guangcan& Xu, Muming& Chen, Jingyao& Hong, Liangli& Lin, Wenting& Zhao, Shukun…[et al.]. 2018. Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192914
Modern Language Association (MLA)
Chen, Guangcan…[et al.]. Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192914
American Medical Association (AMA)
Chen, Guangcan& Xu, Muming& Chen, Jingyao& Hong, Liangli& Lin, Wenting& Zhao, Shukun…[et al.]. Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192914