Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
Joint Authors
Li, Changyi
Zhu, Tao
Chen, Zhihong
Chen, Guihua
Wang, Daoxin
Tang, Shuo
Deng, Huojin
Wang, Jing
Li, Shengjin
Lan, Jian
Tong, Jin
Li, He
Deng, Xinyu
Zhang, Wei
Sun, Jiayang
Tu, Yuesheng
Luo, Wanting
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Asthma is characterized by airway inflammation and mucus hypersecretion.
Curcumin possessed a potent anti-inflammatory property involved in the PPARγ-dependent NF-κB signaling pathway.
Then, the aim of the current study was to explore the value of curcumin in asthmatic airway inflammation and mucus secretion and its underlying mechanism.
In vivo, mice were sensitized and challenged by ovalbumin (OVA) to induce chronic asthma.
Airway inflammation and mucus secretion were analyzed.
In vitro, BEAS-2B cells were obtained.
MCP-1, MUC5AC, and PPARγ expression and the phosphorylation of NF-κB p65 and NF-κB p65 DNA-binding activity were measured in both the lungs and BEAS-2B cells.
shRNA-PPARγ was used to knock down PPARγ expression.
We found that OVA-induced airway inflammation and mucus hypersecretion in mice, OVA and IL-4-induced upregulation of MCP-1 and MUC5AC, suppression of PPARγ, and activation and translocation of NF-κB p65 were notably improved by curcumin both in vivo and in vitro.
Our data also showed that these effects of curcumin were significantly abrogated by shRNA-PPARγ.
Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARγ-dependent NF-κB signaling pathway.
American Psychological Association (APA)
Zhu, Tao& Chen, Zhihong& Chen, Guihua& Wang, Daoxin& Tang, Shuo& Deng, Huojin…[et al.]. 2019. Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192918
Modern Language Association (MLA)
Zhu, Tao…[et al.]. Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro. Mediators of Inflammation No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1192918
American Medical Association (AMA)
Zhu, Tao& Chen, Zhihong& Chen, Guihua& Wang, Daoxin& Tang, Shuo& Deng, Huojin…[et al.]. Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192918