Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets
Joint Authors
Ao, Qiang
Li, Hanrong
Bai, Shuling
Wang, Xiaohong
Tian, Xiaohong
Li, Xiang
Tong, Hao
Hou, Weijian
Fan, Jun
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic degenerative process of the abdominal aorta.
In this process, inflammatory responses and immune system work efficiently by inflammatory cell attraction, proinflammatory factor secretion and subsequently MMP upregulation.
Previous studies have demonstrated various inflammatory cell types in AAA of human and animals.
The majority of cells, such as macrophages, CD4+ T cells, and B cells, play an important role in the diseased aortic wall through phenotypic modulation.
Furthermore, immunoglobulins also greatly affect the functions and differentiation of immune cells in AAA.
Recent evidence suggests that innate immune system, especially Toll-like receptors, chemokine receptors, and complements are involved in the progression of AAAs.
We discussed the innate immune system, inflammatory cells, immunoglobulins, immune-mediated mechanisms, and key cytokines in the pathogenesis of AAA and particularly emphasis on a further trend and application of these interventions.
This current understanding may offer new insights into the role of inflammation and immune response in AAA.
American Psychological Association (APA)
Li, Hanrong& Bai, Shuling& Ao, Qiang& Wang, Xiaohong& Tian, Xiaohong& Li, Xiang…[et al.]. 2018. Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192920
Modern Language Association (MLA)
Li, Hanrong…[et al.]. Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets. Journal of Immunology Research No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1192920
American Medical Association (AMA)
Li, Hanrong& Bai, Shuling& Ao, Qiang& Wang, Xiaohong& Tian, Xiaohong& Li, Xiang…[et al.]. Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192920