Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation
Author
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We recently developed a new allogeneic hematopoietic stem cell transplantation method (allo-HSCT) combined with thymus transplantation (TT) from the same donor (allo-HSCT + TT).
This method induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and HSCT + donor lymphocyte infusion (DLI).
This new method is effective against several intractable diseases, including malignant tumors, for which conventional treatments are ineffective.
Regulatory T (Treg) cells play an important role in the enhanced graft-versus-tumor (GVT) effect and reduction of GVHD, thus leading to longer survival.
Replacement and reduction of elevated Treg cells by donor-derived allo-Treg cells from the transplanted thymus may play one of crucial roles in the effect.
This review discusses the role of Treg cells in a tumor-bearing mouse model treated with allo-HSCT + TT.
American Psychological Association (APA)
Hosaka, Naoki. 2018. Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192929
Modern Language Association (MLA)
Hosaka, Naoki. Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192929
American Medical Association (AMA)
Hosaka, Naoki. Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192929