Differences in cNOSiNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice
Joint Authors
Rizzo, Luiz Vicente
Pinge-Filho, Phileno
Yamauchi, Lucy Megumi
Yamada-Ogatta, Sueli Fumie
Panis, Carolina
Tatakihara, Vera Lúcia Hideko
Martins-Pinge, Marli Cardoso
Jacob, Vanessa
Cecchini, Rubens
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Infection with the protozoan Trypanosoma cruzi causes Chagas disease and consequently leads to severe inflammatory heart condition; however, the mechanisms driving this inflammatory response have not been completely elucidated.
Nitric oxide (NO) is a key mediator of parasite killing in T.
cruzi-infected mice, and previous studies have suggested that leukotrienes (LTs) essentially regulate the NO activity in the heart.
We used infected 5-lipoxygenase-deficient mice (5-LO−/−) to explore the participation of nitric oxide synthase isoforms, inducible (iNOS) and constitutive (cNOS), in heart injury, cytokine profile, and oxidative stress during the early stage of T.
cruzi infection.
Our evidence suggests that the cNOS of the host is involved in the resistance of 5-LO−/− mice during T.
cruzi infection.
iNOS inhibition generated a remarkable increase in T.
cruzi infection in the blood and heart of mice, whereas cNOS inhibition reduced cardiac parasitism (amastigote nests).
Furthermore, this inhibition associates with a higher IFN-γ production and lower lipid peroxidation status.
These data provide a better understanding about the influence of NO-interfering therapies for the inflammatory response toward T.
cruzi infection.
American Psychological Association (APA)
Panis, Carolina& Jacob, Vanessa& Tatakihara, Vera Lúcia Hideko& Cecchini, Rubens& Rizzo, Luiz Vicente& Yamauchi, Lucy Megumi…[et al.]. 2019. Differences in cNOSiNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192931
Modern Language Association (MLA)
Panis, Carolina…[et al.]. Differences in cNOSiNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1192931
American Medical Association (AMA)
Panis, Carolina& Jacob, Vanessa& Tatakihara, Vera Lúcia Hideko& Cecchini, Rubens& Rizzo, Luiz Vicente& Yamauchi, Lucy Megumi…[et al.]. Differences in cNOSiNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192931