The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Joint Authors
Li, Huiping
Kolb, Martin
Weng, Dong
Chen, Xian-Qiu
Qiu, Hui
Zhang, Yuan
Li, Qiu-Hong
Zhao, Meng-Meng
Wu, Qin
Chen, Tao
Hu, Yang
Wang, Liu-Sheng
Wei, Ya-Ru
Du, Yu-Kui
Chen, Shan-Shan
Zhou, Ying
Zhang, Fen
Shen, Li
Su, Yi-Liang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Acute exacerbation of IPF (AE-IPF) is associated with high mortality.
We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF.
Objectives.
Our purpose is to investigate the role of infection in AE-IPF.
Methods.
Overall, we recruited 170 IPF patients (48 AE-IPF, 122 stable) and 70 controls at Shanghai Pulmonary Hospital.
Specific IgM against microbial pathogens and pathogens in sputum were assessed.
RNA sequences of pathogens in nasopharyngeal swab of IPF patients were detected by PathChip.
A panel of serum parameters reflecting immune function were assessed.
Results.
Antiviral/bacterial IgM was higher in IPF vs.
controls and in AE-IPF vs.
stable IPF.
Thirty-eight different bacterial strains were detected in IPF patient sputum.
Bacteria-positive results were found in 9/48 (18.8%) of AE-IPF and in 26/122 (21.3%) stable IPF.
Fifty-seven different viruses were detected in nasopharyngeal swabs of IPF patients.
Virus-positive nasopharyngeal swabs were found in 18/30 (60%) of tested AE-IPF and in 13/30 (43.3%) of stable IPF.
AE-IPF showed increased inflammatory cytokines (IL-6, IFN-γ, MIG, IL-17, and IL-9) vs.
stable IPF and controls.
Mortality of AE-IPF in one year (39.5%) was higher compared to stable IPF (28.7%).Conclusions.
IPF patients had different colonization with pathogens in sputum and nasopharyngeal swabs; they also displayed abnormally activated immune response, which was exacerbated during AE-IPF.
American Psychological Association (APA)
Weng, Dong& Chen, Xian-Qiu& Qiu, Hui& Zhang, Yuan& Li, Qiu-Hong& Zhao, Meng-Meng…[et al.]. 2019. The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192933
Modern Language Association (MLA)
Weng, Dong…[et al.]. The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1192933
American Medical Association (AMA)
Weng, Dong& Chen, Xian-Qiu& Qiu, Hui& Zhang, Yuan& Li, Qiu-Hong& Zhao, Meng-Meng…[et al.]. The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192933