The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections.
It becomes activated after arousal and novelty, whereupon noradrenaline is released in the hippocampus.
Noradrenaline from the locus coeruleus is involved in modulating the encoding, consolidation, retrieval, and reversal of hippocampus-based memory.
Memory storage can be modified by the activation of the locus coeruleus and subsequent facilitation of hippocampal long-term plasticity in the forms of long-term depression and long-term potentiation.
Recent evidence indicates that noradrenaline and dopamine are coreleased in the hippocampus from locus coeruleus terminals, thus fostering neuromodulation of long-term synaptic plasticity and memory.
Noradrenaline is an inductor of epigenetic modifications regulating transcriptional control of synaptic long-term plasticity to gate the endurance of memory storage.
In conclusion, locus coeruleus activation primes the persistence of hippocampus-based long-term memory.
American Psychological Association (APA)
Hansen, Niels. 2017. The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System. Neural Plasticity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1192938
Modern Language Association (MLA)
Hansen, Niels. The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System. Neural Plasticity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1192938
American Medical Association (AMA)
Hansen, Niels. The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1192938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192938