![](/images/graphics-bg.png)
Low-Frequency Repetitive Transcranial Magnetic Stimulation for Stroke-Induced Upper Limb Motor Deficit: A Meta-Analysis
Joint Authors
Xing, Guoqiang
Guo, Zhiwei
Chen, Huaping
McClure, Morgan A.
Mu, Qiwen
Zhang, Lan
Shuai, Shiquan
Chen, Xiaojuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background and Purpose.
This meta-analysis aimed to evaluate the therapeutic potential of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) over the contralesional hemisphere on upper limb motor recovery and cortex plasticity after stroke.
Methods.
Databases of PubMed, Medline, ScienceDirect, Cochrane, and Embase were searched for randomized controlled trials published before Jun 31, 2017.
The effect size was evaluated by using the standardized mean difference (SMD) and a 95% confidence interval (CI).
Resting motor threshold (rMT) and motor-evoked potential (MEP) were also examined.
Results.
Twenty-two studies of 1 Hz LF-rTMS over the contralesional hemisphere were included.
Significant efficacy was found on finger flexibility (SMD = 0.75), hand strength (SMD = 0.49), and activity dexterity (SMD = 0.32), but not on body function (SMD = 0.29).
The positive changes of rMT (SMD = 0.38 for the affected hemisphere and SMD = −0.83 for the unaffected hemisphere) and MEP (SMD = −1.00 for the affected hemisphere and SMD = 0.57 for the unaffected hemisphere) were also significant.
Conclusions.
LF-rTMS as an add-on therapy significantly improved upper limb functional recovery especially the hand after stroke, probably through rebalanced cortical excitability of both hemispheres.
Future studies should determine if LF-rTMS alone or in conjunction with practice/training would be more effective.
Clinical Trial Registration Information.
This trial is registered with unique identifier CRD42016042181.
American Psychological Association (APA)
Zhang, Lan& Xing, Guoqiang& Shuai, Shiquan& Guo, Zhiwei& Chen, Huaping& McClure, Morgan A.…[et al.]. 2017. Low-Frequency Repetitive Transcranial Magnetic Stimulation for Stroke-Induced Upper Limb Motor Deficit: A Meta-Analysis. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192942
Modern Language Association (MLA)
Zhang, Lan…[et al.]. Low-Frequency Repetitive Transcranial Magnetic Stimulation for Stroke-Induced Upper Limb Motor Deficit: A Meta-Analysis. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1192942
American Medical Association (AMA)
Zhang, Lan& Xing, Guoqiang& Shuai, Shiquan& Guo, Zhiwei& Chen, Huaping& McClure, Morgan A.…[et al.]. Low-Frequency Repetitive Transcranial Magnetic Stimulation for Stroke-Induced Upper Limb Motor Deficit: A Meta-Analysis. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192942