Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity.
Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease.
Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs.
In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer’s disease, efforts in boosting NMDAR activity/functions have surged in recent years.
In this review, we will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of NMDARs.
We shall also discuss the usefulness of these newly developed NMDAR-PAMs.
American Psychological Association (APA)
Yao, Lulu& Zhou, Qiang. 2017. Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1192947
Modern Language Association (MLA)
Yao, Lulu& Zhou, Qiang. Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1192947
American Medical Association (AMA)
Yao, Lulu& Zhou, Qiang. Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1192947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192947