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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells
Joint Authors
Li, He-Ming
Wang, Ruo-Yu
Li, Xuefeng
Wang, Zhe
Liu, Guangyan
Mao, Jiwei
Xie, Min
Zhao, Ming
Guo, Xuefen
Liang, Shanshan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients.
The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival.
Thus, IGF-1R may be a potential therapeutic target for patients with different malignancies.
However, its mechanism in NPC is not fully investigated.
Linsitinib is an oral small molecule and is a tyrosine kinase inhibitor (TKI) of IGF-1R, which has been known for antitumor effects used widely.
Here, we evaluated the proliferation and radiosensitivity of NPC cell lines (CNE-2 and SUNE-1) after linsitinib treatment.
We found that linsitinib suppresses IGF-1-induced cell proliferation through inhibiting Akt and ERK phosphorylation.
Moreover, linsitinib further boosted IR-induced DNA damage, G2-M cell cycle delay, and apoptosis in NPC cells.
Finally, linsitinib reversed radioresistant NPC cells by decreasing the phosphorylation of IGF-1R.
Our data indicated that the combination of linsitinib and IR and targeting IGF-1R by linsitinib could be a promising therapeutic strategy for NPC.
American Psychological Association (APA)
Wang, Zhe& Liu, Guangyan& Mao, Jiwei& Xie, Min& Zhao, Ming& Guo, Xuefen…[et al.]. 2019. IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192955
Modern Language Association (MLA)
Wang, Zhe…[et al.]. IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192955
American Medical Association (AMA)
Wang, Zhe& Liu, Guangyan& Mao, Jiwei& Xie, Min& Zhao, Ming& Guo, Xuefen…[et al.]. IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192955