Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells
Joint Authors
Brzezińska-Błaszczyk, Ewa
Agier, Justyna
Różalska, Sylwia
Żelechowska, Paulina
Pietrzak, Jacek
Wiktorska, Magdalena
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-19
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Undoubtedly, mast cells take part in host defense against microorganisms as they are numerous at the portal of infection, they release many proinflammatory and antimicrobial mediators, and they express pattern recognition receptors, such as TLRs.
These receptors play a key role in recognition and binding molecules associated with microorganisms and molecules associated with damage.
Cathelicidins exhibit direct antimicrobial activities against a broad spectrum of microbes by perturbing their cell membranes.
Accumulating evidence suggests a role for these molecules in supporting cell activation.
We examined the impact of human cathelicidin LL-37 on tissue mast cell TLR expression and distribution.
Depending on context, we show that LL-37 stimulation resulted in minor to major effects on TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9 expression.
Confocal microscopy analysis showed that, upon stimulation, TLRs may translocate from the cell interior to the surface and conversely.
FPR2 and EGFR inhibitors reduced the increase in expression of selected receptors.
We also established that LL-37 acts as a powerful inducer of CCL3 and ROS generation.
These results showed that in response to LL-37, mast cells enhance the capability to detect invading pathogens by modulation of TLR expression in what may be involved FPR2 or EGFR molecules.
American Psychological Association (APA)
Agier, Justyna& Brzezińska-Błaszczyk, Ewa& Żelechowska, Paulina& Wiktorska, Magdalena& Pietrzak, Jacek& Różalska, Sylwia. 2018. Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192956
Modern Language Association (MLA)
Agier, Justyna…[et al.]. Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1192956
American Medical Association (AMA)
Agier, Justyna& Brzezińska-Błaszczyk, Ewa& Żelechowska, Paulina& Wiktorska, Magdalena& Pietrzak, Jacek& Różalska, Sylwia. Cathelicidin LL-37 Affects Surface and Intracellular Toll-Like Receptor Expression in Tissue Mast Cells. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192956