Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis
Joint Authors
Li, Yuxuan
Yuan, Lin
Yang, Jie
Lei, Yue
Zhang, Hui
Xia, Liping
Shen, Hui
Lu, Jing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Tofacitinib is a novel therapy for rheumatoid arthritis (RA).
The aim of this study was to measure various serum cytokines levels and to explore potential markers predictive of therapeutic efficacy of tofacitinib for RA patients.
Methods.
Thirty-two patients with RA were given tofacitinib (5 mg bid).
Serum cytokines levels of Th1 (IFN-γ), Th2 (IL-6), Th17 (IL-17), Tregs (IL-35), and TNF-α were detected by enzyme-linked immunosorbent assays.
Results.
Disease activity was significantly decreased as early as week 4 after tofacitinib treatment.
Serum IL-35 levels were significantly increased and serum levels of TNF-α, IL-17, IL-6, and IFN-γ were significantly reduced in response to tofacitinib since week 4.
Conclusions.
After treatment with tofacitinib, RA patients may benefit from monitoring of disease activity as early as week 4.
IL-35 also might be a predictive indicator of the disease activity and drug efficacy.
Meanwhile, tofacitinib might be CS-sparing in RA.
American Psychological Association (APA)
Li, Yuxuan& Yuan, Lin& Yang, Jie& Lei, Yue& Zhang, Hui& Xia, Liping…[et al.]. 2019. Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192957
Modern Language Association (MLA)
Li, Yuxuan…[et al.]. Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192957
American Medical Association (AMA)
Li, Yuxuan& Yuan, Lin& Yang, Jie& Lei, Yue& Zhang, Hui& Xia, Liping…[et al.]. Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192957