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Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease
Joint Authors
Lippa, Carol F.
Boffo, S.
Xu, Lingyan
Ren, Zhiyun
Chow, Frances E.
Tsai, Richard
Liu, Tongzheng
Rizzolio, Flavio
Xu, Yungen
Huang, Shaohui
Gong, Yuesong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Synaptic loss is the structural basis for memory impairment in Alzheimer’s disease (AD).
While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau tangles decades before the onset of clinical disease.
The loss of Pin1 facilitates the formation of these misfolded proteins in AD.
Pin1 protein controls cell-cycle progression and determines the fate of proteins by the ubiquitin proteasome system.
The activity of the ubiquitin proteasome system directly affects the functional and structural plasticity of the synapse.
We localized Pin1 to dendritic rafts and postsynaptic density (PSD) and found the pathological loss of Pin1 within the synapses of AD brain cortical tissues.
The loss of Pin1 activity may alter the ubiquitin-regulated modification of PSD proteins and decrease levels of Shank protein, resulting in aberrant synaptic structure.
The loss of Pin1 activity, induced by oxidative stress, may also render neurons more susceptible to the toxicity of oligomers of Aβ and to excitation, thereby inhibiting NMDA receptor-mediated synaptic plasticity and exacerbating NMDA receptor-mediated synaptic degeneration.
These results suggest that loss of Pin1 activity could lead to the loss of synaptic plasticity in the development of AD.
American Psychological Association (APA)
Xu, Lingyan& Ren, Zhiyun& Chow, Frances E.& Tsai, Richard& Liu, Tongzheng& Rizzolio, Flavio…[et al.]. 2017. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192959
Modern Language Association (MLA)
Xu, Lingyan…[et al.]. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1192959
American Medical Association (AMA)
Xu, Lingyan& Ren, Zhiyun& Chow, Frances E.& Tsai, Richard& Liu, Tongzheng& Rizzolio, Flavio…[et al.]. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192959