Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model
Joint Authors
Kölliker-Frers, R. A.
Capani, F.
Herrera, María Inés
Udovin, Lucas Daniel
Kusnier, Carlos
de Souza, Wanderley
Otero-Losada, Matilde
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function.
Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development.
Perinatal asphyxia is associated with high morbimortality in term and preterm neonates.
Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia.
Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved.
Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.
American Psychological Association (APA)
Herrera, María Inés& Otero-Losada, Matilde& Udovin, Lucas Daniel& Kusnier, Carlos& Kölliker-Frers, R. A.& de Souza, Wanderley…[et al.]. 2017. Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model. Neural Plasticity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1192961
Modern Language Association (MLA)
Herrera, María Inés…[et al.]. Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model. Neural Plasticity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1192961
American Medical Association (AMA)
Herrera, María Inés& Otero-Losada, Matilde& Udovin, Lucas Daniel& Kusnier, Carlos& Kölliker-Frers, R. A.& de Souza, Wanderley…[et al.]. Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1192961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192961