FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling
Joint Authors
Xu, Congjian
Zhang, Zhigang
Sun, Su-an
Tai, Haiyan
Wu, Zhiyong
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fibroblast growth factor receptor-like-1 (FGFRL1) has been identified as the fifth fibroblast growth factor receptor.
So far, little is known about its biological functions, particularly in cancer development.
Here, for the first time, we demonstrated the roles of FGFRL1 in ovarian carcinoma (OC).
An array and existing databases were used to investigate the expression profile of FGFRL1 and the relationship between FGFRL1 expression and clinicopathological parameters.
FGFRL1 was significantly upregulated in OC patients, and high FGFRL1 expression was correlated with poor prognosis.
In vitro cell proliferation, apoptosis and migration assays, and in vivo subcutaneous xenograft tumor models were used to determine the role of FGFRL1.
Loss of function of FGFRL1 significantly influenced cell proliferation, apoptosis, and migration of OC cells in vitro and tumor growth in vivo.
Chromatin immunoprecipitation PCR analysis and microarray hybridization were performed to uncover the mechanism.
FGFRL1 expression could be induced by hypoxia through hypoxia-inducible factor 1α, which directly binds to the promoter elements of FGFRL1.
FGFRL1 promoted tumor progression by crosstalk with Hedgehog (Hh) signaling.
Taken together, FGFRL1 is a potential predictor and plays an important role in tumor growth and Hh signaling which could serve as potential therapeutic targets for the treatment of OC.
American Psychological Association (APA)
Tai, Haiyan& Wu, Zhiyong& Sun, Su-an& Zhang, Zhigang& Xu, Congjian. 2018. FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192966
Modern Language Association (MLA)
Tai, Haiyan…[et al.]. FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192966
American Medical Association (AMA)
Tai, Haiyan& Wu, Zhiyong& Sun, Su-an& Zhang, Zhigang& Xu, Congjian. FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192966