A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1
Joint Authors
Wang, Zhongli
Zhu, Chan
Yuan, Xiaolin
Yu, Guang
Tang, Zongxiang
Hu, Danyou
Wang, Changming
Li, Fengxian
Su, Shulan
Yang, Niuniu
Yang, Yan
Shi, Hao
Yu, Lei
Geng, Xiao
Gu, Leying
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Frankincense and myrrh are widely used in clinics as a pair of herbs to obtain a synergistic effect for relieving pain.
To illuminate the analgesia mechanism of frankincense and myrrh, we assessed its effect in a neuropathic pain mouse model.
Transient receptor potential vanilloid 1 (TRPV1) plays a crucial role in neuropathic pain and influences the plasticity of neuronal connectivity.
We hypothesized that the water extraction of frankincense and myrrh (WFM) exerted its analgesia effect by modulating the neuronal function of TRPV1.
In our study, WFM was verified by UHPLC-TQ/MS assay.
In vivo study showed that nociceptive response in mouse by heat and capsaicin induced were relieved by WFM treatment.
Furthermore, thermal hypersensitivity and mechanical allodynia were also alleviated by WFM treatment in a chronic constriction injury (CCI) mouse model.
CCI resulted in increased TRPV1 expression at both the mRNA and protein levels in predominantly small-to-medium neurons.
However, after WFM treatment, TRPV1 expression was reverted in real-time PCR, Western blot, and immunofluorescence experiments.
Calcium response to capsaicin was also decreased in cultured DRG neurons from CCI model mouse after WFM treatment.
In conclusion, WFM alleviated CCI-induced mechanical allodynia and thermal hypersensitivity via modulating TRPV1.
American Psychological Association (APA)
Hu, Danyou& Wang, Changming& Li, Fengxian& Su, Shulan& Yang, Niuniu& Yang, Yan…[et al.]. 2017. A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1192977
Modern Language Association (MLA)
Hu, Danyou…[et al.]. A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1192977
American Medical Association (AMA)
Hu, Danyou& Wang, Changming& Li, Fengxian& Su, Shulan& Yang, Niuniu& Yang, Yan…[et al.]. A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1192977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192977