The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain
Joint Authors
Liang, Yi
Shao, Xiao-mei
Fang, Jun-fan
Du, Jun-ying
Wen, Cun
Fang, Jian-Qiao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic inflammatory pain can induce emotional diseases.
Electroacupuncture (EA) has effects on chronic pain and pain-related anxiety.
Protein kinase Mzeta (PKMzeta) has been proposed to be essential for the maintenance of pain and may interact with GluR1 to maintain CNS plasticity in the anterior cingulate cortex (ACC).
We hypothesized that the PKMzeta-GluR1 pathway in the ACC may be involved in anxiety-like behaviors of chronic inflammatory pain and that the mechanism of EA regulation of pain emotion may involve the PKMzeta pathway in the ACC.
Our results showed that chronic inflammatory pain model decreased the paw withdrawal threshold (PWT) and increased anxiety-like behaviors.
The protein expression of PKCzeta, p-PKCzeta (T560), PKMzeta, p-PKMzeta (T560), and GluR1 in the ACC of the model group were remarkably enhanced.
EA increased PWT and alleviated anxiety-like behaviors.
EA significantly inhibited the protein expression of p-PKMzeta (T560) in the ACC, and only a downward trend effect for other substances.
Further, the microinjection of ZIP remarkably reversed PWT and anxiety-like behaviors.
The present study provides direct evidence that the PKCzeta/PKMzeta-GluR1 pathway is related to pain and pain-induced anxiety-like behaviors.
EA treatment both increases pain-related somatosensory behavior and decreases pain-induced anxiety-like behaviors by suppressing PKMzeta activity in the ACC.
American Psychological Association (APA)
Du, Jun-ying& Fang, Jun-fan& Wen, Cun& Shao, Xiao-mei& Liang, Yi& Fang, Jian-Qiao. 2017. The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain. Neural Plasticity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1192978
Modern Language Association (MLA)
Du, Jun-ying…[et al.]. The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain. Neural Plasticity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1192978
American Medical Association (AMA)
Du, Jun-ying& Fang, Jun-fan& Wen, Cun& Shao, Xiao-mei& Liang, Yi& Fang, Jian-Qiao. The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1192978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192978