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Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats.
Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation.
Evidence suggests that a circadian regulation mechanism allows for a timestamping of such fear memories and controlling memory salience during both their acquisition and their modification after retrieval.
These mechanisms include an expression of molecular clocks in neurons of the amygdala, hippocampus, and medial prefrontal cortex and their tight interaction with the intracellular signaling pathways that mediate neural plasticity and information storage.
The cellular activities are coordinated across different brain regions and neural circuits through the release of glucocorticoids and neuromodulators such as acetylcholine, which integrate circadian and memory-related activation.
Disturbance of this interplay by circadian phase shifts or traumatic experience appears to be an important factor in the development of stress-related psychopathology, considering these circadian components are of critical importance for optimizing therapeutic approaches to these disorders.
American Psychological Association (APA)
Albrecht, Anne& Stork, Oliver. 2017. Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192979
Modern Language Association (MLA)
Albrecht, Anne& Stork, Oliver. Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1192979
American Medical Association (AMA)
Albrecht, Anne& Stork, Oliver. Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192979