Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies
Joint Authors
Kohl, Zacharias
Feldewerth, Judith
Hornauer, Philipp
Münch, Martina
Adame, Anthony
Riemenschneider, Markus J.
Schlachetzki, Johannes C. M.
Winkler, Jürgen
Masliah, Eliezer
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer’s disease (AD) and Parkinson’s disease (PD).
The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain.
In turn, alterations of this cellular plasticity are related to neuroinflammation such as microglia activation, implicated in the pathogenesis of AD and PD, as well as frontotemporal lobe degeneration (FTLD).
To determine microglia proliferation and activation we analyzed ionized calcium binding adaptor molecule 1 (Iba1) expressing microglia in the glomerular and granular cell layer, and the olfactory tract of the OB from patients with AD, PD dementia/dementia with Lewy bodies (PDD/DLB), and FTLD compared to age-matched controls.
The number of Iba1 and CD68 positive microglia associated with enlarged amoeboid microglia was increased particularly in AD, to a lesser extent in FTLD and PDD/DLB as well, while the proportion of proliferating microglia was not altered.
In addition, cells expressing the immature neuronal marker polysialylated neural cell adhesion molecule (PSA-NCAM) were increased in the glomerular layer of PDD/DLB and FTLD cases only.
These findings provide novel and detailed insights into differential levels of microglia activation in the OB of neurodegenerative diseases.
American Psychological Association (APA)
Kohl, Zacharias& Schlachetzki, Johannes C. M.& Feldewerth, Judith& Hornauer, Philipp& Münch, Martina& Adame, Anthony…[et al.]. 2017. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plasticity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1192984
Modern Language Association (MLA)
Kohl, Zacharias…[et al.]. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plasticity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1192984
American Medical Association (AMA)
Kohl, Zacharias& Schlachetzki, Johannes C. M.& Feldewerth, Judith& Hornauer, Philipp& Münch, Martina& Adame, Anthony…[et al.]. Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1192984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192984