The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma
Joint Authors
Zhao, Xueyun
Hua, Mingqiang
Yan, Shuxin
Yu, Jie
Han, Fengjiao
Zhong, Chaoqin
Wang, Ruiqing
Zhang, Chen
Hou, Ming
Ma, Daoxin
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The pathogenesis of multiple myeloma (MM) remains unclear and the NLRP3 inflammasome has been more and more recognized in the progression of many diseases.
To investigate the role of the NLRP3 inflammasome in MM, we determined the genetic polymorphisms and expression of NLRP3 inflammasome-related genes (IL-1β, IL-18, CARD8, and NF-κB) in MM patients, and explored their clinical relevance.
Furthermore, we investigated the relationship of the NLRP3 inflammasome with Th cells in MM.
Our study showed that the CARD8-C10X (rs2043211) AT genotype contributed to the susceptibility of MM.
CARD8-C10X TT patients had earlier clinical stage.
The WBC count in the three CARD8 genotypes showed an increasing trend (AA Compared with patients with NF-κB-94 ins/del ATTG ins/ins and ins/del, patients with del/del had the highest myeloma cell ratio. Patients with IL-18 (rs16944) TT had the highest hemoglobin concentration (GG Furthermore, we found that the genotype of CARD8-C10X (rs2043211) or NF-κB-94 ins/del ATTG was closely related to the frequency of Th1. Therefore, the genetic polymorphisms of the NLRP3 inflammasome associated with Th cells might be involved in the pathogenesis of multiple myeloma.
American Psychological Association (APA)
Zhao, Xueyun& Hua, Mingqiang& Yan, Shuxin& Yu, Jie& Han, Fengjiao& Zhong, Chaoqin…[et al.]. 2018. The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192990
Modern Language Association (MLA)
Zhao, Xueyun…[et al.]. The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1192990
American Medical Association (AMA)
Zhao, Xueyun& Hua, Mingqiang& Yan, Shuxin& Yu, Jie& Han, Fengjiao& Zhong, Chaoqin…[et al.]. The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192990