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Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?
Joint Authors
Pilloni, Andrea
Valesini, Guido
Polimeni, Antonella
Saccucci, Matteo
Di Carlo, Gabriele
Ceccarelli, Fulvia
Pranno, Nicola
Luzzi, Valeria
Lucchetti, Ramona
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The strict link between periodontitis (PD) and rheumatoid arthritis (RA) has been widely demonstrated by several studies.
PD is significantly more frequent in RA patients in comparison with healthy subjects: this prevalence is higher in individuals at the earliest stages of disease and in seropositive patients.
This is probably related to the role of P.
gingivalis in inducing citrullination and leading to the development of the new antigens.
Despite the many studies conducted on this topic, there is very little data available concerning the possibility to use the same biomarkers to evaluate both RA and PD patients.
The aim of the review is to summarize this issue.
Starting from genetic factors, data from literature demonstrated the association between HLA-DRB1 alleles and PD susceptibility, similar to RA patients; moreover, SE-positive patients showed simultaneously structural damage to the wrist and periodontal sites.
Contrasting results are available concerning other genetic polymorphisms.
Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue.
American Psychological Association (APA)
Ceccarelli, Fulvia& Saccucci, Matteo& Di Carlo, Gabriele& Lucchetti, Ramona& Pilloni, Andrea& Pranno, Nicola…[et al.]. 2019. Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192997
Modern Language Association (MLA)
Ceccarelli, Fulvia…[et al.]. Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192997
American Medical Association (AMA)
Ceccarelli, Fulvia& Saccucci, Matteo& Di Carlo, Gabriele& Lucchetti, Ramona& Pilloni, Andrea& Pranno, Nicola…[et al.]. Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192997