Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure
Joint Authors
Tan, Xing
Wang, Wei-Zhong
Ren, Chang-zhen
Wang, Wei
Zou, Zui
Zhang, Ru-Wen
Yao, Xue-Ya
Li, Cheng-Bao
Shi, Xue-Yin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neuropathic pain increases the risk of cardiovascular diseases including hypertension with the characteristic of sympathetic overactivity.
The enhanced tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM) contributes to sympathetic overactivity and blood pressure (BP) in cardiovascular diseases.
We hypothesize that neuropathic pain enhances tonically active glutamatergic inputs to the RVLM, which contributes to high level of BP and sympathetic outflow.
Animal model with the trigeminal neuropathic pain was induced by the infraorbital nerve-chronic constriction injury (ION-CCI).
A significant increase in BP and renal sympathetic nerve activity (RSNA) was found in rats with ION-CCI (BP, n=5, RSNA, n=7, p<0.05).
The concentration of glutamate in the RVLM was significantly increased in the ION-CCI group (n=4, p<0.05).
Blockade of glutamate receptors by injection of kynurenic acid into the RVLM significantly decreased BP and RSNA in the ION-CCI group (n=5, p<0.05).
In two major sources (the paraventricular nucleus and periaqueductal gray) for glutamatergic inputs to the RVLM, the ION-CCI group (n=5, p<0.05) showed an increase in glutamate content and expression of glutaminase 2, vesicular glutamate transporter 2 proteins, and c-fos.
Our results suggest that enhancement in tonically active glutamatergic inputs to the RVLM contributes to neuropathic pain-induced high blood pressure.
American Psychological Association (APA)
Wang, Wei& Zou, Zui& Tan, Xing& Zhang, Ru-Wen& Ren, Chang-zhen& Yao, Xue-Ya…[et al.]. 2017. Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure. Neural Plasticity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193002
Modern Language Association (MLA)
Wang, Wei…[et al.]. Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure. Neural Plasticity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193002
American Medical Association (AMA)
Wang, Wei& Zou, Zui& Tan, Xing& Zhang, Ru-Wen& Ren, Chang-zhen& Yao, Xue-Ya…[et al.]. Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193002