Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish
Joint Authors
Bollaerts, Ilse
Van houcke, Jessie
De Groef, Lies
Moons, Lieve
Beckers, An
Lemmens, Kim
Vanhunsel, Sophie
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality.
Recent work has shown that appropriate modulation of acute neuroinflammation upon CNS injury can trigger a regenerative response; yet, the underlying cellular and molecular mechanisms remain largely elusive.
In contrast to mammals, zebrafish retain high regenerative capacities into adulthood and thus form a powerful model to study the contribution of neuroinflammation to successful regeneration.
Here, we used pharmacological immunosuppression methods to study the role of microglia/macrophages during optic nerve regeneration in adult zebrafish.
We first demonstrated that systemic immunosuppression with dexamethasone (dex) impedes regeneration after optic nerve injury.
Secondly, and strikingly, local intravitreal application of dex or clodronate liposomes prior to injury was found to sensitize retinal microglia.
Consequently, we observed an exaggerated inflammatory response to subsequent optic nerve damage, along with enhanced tectal reinnervation.
In conclusion, we found a strong positive correlation between the acute inflammatory response in the retina and the regenerative capacity of the optic nerve in adult zebrafish subjected to nerve injury.
American Psychological Association (APA)
Bollaerts, Ilse& Van houcke, Jessie& Beckers, An& Lemmens, Kim& Vanhunsel, Sophie& De Groef, Lies…[et al.]. 2019. Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1193006
Modern Language Association (MLA)
Bollaerts, Ilse…[et al.]. Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish. Mediators of Inflammation No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1193006
American Medical Association (AMA)
Bollaerts, Ilse& Van houcke, Jessie& Beckers, An& Lemmens, Kim& Vanhunsel, Sophie& De Groef, Lies…[et al.]. Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1193006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193006