Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context
Joint Authors
Mikhaylov, Mikhail I.
Isaguliants, Maria
Kichatova, V. S.
Kyuregyan, K. K.
Soboleva, N. V.
Karlsen, A. A.
Isaeva, O. V.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma.
We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), higher than that in the European (18.0%, p=0.0010), but lower than that in the US HCV 1b strains (62.8%, p<0.0001).
Substitution L91M was found in 80.4% of the Russian HCV 1b isolates, higher than in Asian isolates (43.8%, p<0.0001).
Thus, a significant proportion of Russian HCV 1b isolates carry the unfavorable R70Q/H and/or L91M substitution.
In silico analysis of the epitopic structure of the regions of substitutions revealed that both harbor clusters of T-cell epitopes.
Peptides encompassing these regions were predicted to bind to a panel of HLA class I molecules, with substitutions impairing peptide recognition by HLA I molecules of the alleles prevalent in Russia.
This indicates that HCV 1b with R70Q/H and L91M substitutions may have evolved as the immune escape variants.
Impairment of T-cell recognition may play a part in the negative effect of these substitutions on the response to IFN treatment.
American Psychological Association (APA)
Kichatova, V. S.& Kyuregyan, K. K.& Soboleva, N. V.& Karlsen, A. A.& Isaeva, O. V.& Isaguliants, Maria…[et al.]. 2018. Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1193008
Modern Language Association (MLA)
Kichatova, V. S.…[et al.]. Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1193008
American Medical Association (AMA)
Kichatova, V. S.& Kyuregyan, K. K.& Soboleva, N. V.& Karlsen, A. A.& Isaeva, O. V.& Isaguliants, Maria…[et al.]. Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1193008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193008