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Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma
Joint Authors
Degroote, H.
Van Dierendonck, A.
Geerts, A.
Van Vlierberghe, H.
Devisscher, L.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) most often develops in patients with underlying liver disease characterized by chronic nonresolving inflammation.
Tumor-associated macrophages (TAMs) are one of the most abundant immune cell populations within the tumoral microenvironment.
As key actors of cancer-related inflammation, they promote tumor growth by suppression of effective anticancer immunity, stimulation of angiogenesis, and tissue remodeling.
Therefore, they have become an attractive and promising target for immunotherapy.
The heterogeneity of TAM subtypes and their origin and dynamic phenotype during the initiation and progression of HCC has been partially unraveled and forms the base for the development of therapeutic agents.
Current approaches are aimed at decreasing the population of TAMs by depleting macrophages present in the tumor, blocking the recruitment of bone marrow-derived monocytes, and/or functionally reprogramming TAMs to antitumoral behavior.
In this review, the preclinical evolution and hitherto clinical trials for TAM-targeted therapy in HCC will be highlighted.
American Psychological Association (APA)
Degroote, H.& Van Dierendonck, A.& Geerts, A.& Van Vlierberghe, H.& Devisscher, L.. 2018. Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193010
Modern Language Association (MLA)
Degroote, H.…[et al.]. Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193010
American Medical Association (AMA)
Degroote, H.& Van Dierendonck, A.& Geerts, A.& Van Vlierberghe, H.& Devisscher, L.. Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193010