Brain White Matter Impairment in Patients with Spinal Cord Injury
Joint Authors
Li, Kuncheng
Zheng, Weimin
Chen, Qian
Chen, Xin
Wan, Lu
Qin, Wen
Qi, Zhigang
Chen, Nan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance.
We choose tract-based spatial statistics (TBSS) to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fifteen patients with SCI.
Compared with the healthy controls, the patients exhibited significant decreases in WM fractional anisotropy (FA) in the left angular gyrus (AG), right cerebellum (CB), left precentral gyrus (PreCG), left lateral occipital region (LOC), left superior longitudinal fasciculus (SLF), left supramarginal gyrus (SMG), and left postcentral gyrus (PostCG) (p<0.01, TFCE corrected).
No significant differences were found in all diffusion indices between the complete and incomplete SCI.
However, significantly negative correlation was shown between the increased radial diffusivity (RD) of left AG and total motor scores (uncorrected p<0.05).
Our findings provide evidence that SCI can cause not only direct degeneration but also transneuronal degeneration of brain WM, and these changes may be irrespective of the injury severity.
The affection of left AG on rehabilitation therapies need to be further researched in the future.
American Psychological Association (APA)
Zheng, Weimin& Chen, Qian& Chen, Xin& Wan, Lu& Qin, Wen& Qi, Zhigang…[et al.]. 2017. Brain White Matter Impairment in Patients with Spinal Cord Injury. Neural Plasticity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193023
Modern Language Association (MLA)
Zheng, Weimin…[et al.]. Brain White Matter Impairment in Patients with Spinal Cord Injury. Neural Plasticity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1193023
American Medical Association (AMA)
Zheng, Weimin& Chen, Qian& Chen, Xin& Wan, Lu& Qin, Wen& Qi, Zhigang…[et al.]. Brain White Matter Impairment in Patients with Spinal Cord Injury. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1193023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193023