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The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis
Joint Authors
Mackay, Christopher P.
Brauer, Sandra G.
Kuys, Suzanne S.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) levels in people with neurological disorders.
Data Sources.
Six electronic databases (CINAHL, PubMed, Cochrane, PsycINFO, SportDiscus, and Web of Science) were searched until the end of December 2016.
Study Selection.
Experimental or observational studies of people with neurological disorders who undertook an exercise intervention with BDNF as an outcome measure.
The search strategy yielded 984 articles.
Data Extraction.
Study data were independently extracted from each article.
Methodological quality of studies was assessed using the Physiotherapy Evidence Database (PEDro) scale.
A meta-analysis was planned based on the assessment of predetermined criteria.
Data Synthesis.
Eleven articles were included.
Studies employed either a program of aerobic exercise, a single bout of aerobic exercise, or both.
A meta-analysis of studies comparing a program of aerobic exercise against usual care/nil therapy showed a large effect (SMD: 0.84, 95% CI 0.47–1.20, p<0.001) in favour of aerobic exercise to increase levels of BDNF.
Findings for a single bout of aerobic exercise were mixed.
Quality of studies was low (PEDro average score 4.3/10).
Conclusions.
A program of aerobic exercise may contribute to increased levels of BDNF in neurological populations.
American Psychological Association (APA)
Mackay, Christopher P.& Kuys, Suzanne S.& Brauer, Sandra G.. 2017. The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis. Neural Plasticity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193024
Modern Language Association (MLA)
Mackay, Christopher P.…[et al.]. The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis. Neural Plasticity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193024
American Medical Association (AMA)
Mackay, Christopher P.& Kuys, Suzanne S.& Brauer, Sandra G.. The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193024