![](/images/graphics-bg.png)
Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse
Joint Authors
De Nobrega, Aliza K.
Lyons, Lisa C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles.
The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics.
The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse.
Invertebrate models, such as Drosophila melanogaster, have proven invaluable for the identification of genetic and molecular mechanisms underlying highly conserved processes including the circadian clock, drug tolerance, and reward systems.
In this review, we highlight the contributions of Drosophila as a model system for understanding the bidirectional interactions between the circadian system and the drugs of abuse, alcohol and cocaine, and illustrate the highly conserved nature of these interactions between Drosophila and mammalian systems.
Research in Drosophila provides mechanistic insights into the corresponding behaviors in higher organisms and can be used as a guide for targeted inquiries in mammals.
American Psychological Association (APA)
De Nobrega, Aliza K.& Lyons, Lisa C.. 2017. Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. Neural Plasticity،Vol. 2017, no. 2017, pp.1-28.
https://search.emarefa.net/detail/BIM-1193028
Modern Language Association (MLA)
De Nobrega, Aliza K.& Lyons, Lisa C.. Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. Neural Plasticity No. 2017 (2017), pp.1-28.
https://search.emarefa.net/detail/BIM-1193028
American Medical Association (AMA)
De Nobrega, Aliza K.& Lyons, Lisa C.. Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-28.
https://search.emarefa.net/detail/BIM-1193028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193028