Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1Smad3 and TGF-β1p38 MAPK Pathways
Joint Authors
Liu, Qing
Feng, Jiao
Lu, Xiya
Liu, Ning
Yao, Zhilu
Lv, Yang
Han, Yuru
Deng, Jingfan
Zhou, Ying-Qun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
Liver fibrosis is a consequence of wound-healing responses to chronic liver insult and may progress to liver cirrhosis if not controlled.
This study investigated the protection against liver fibrosis by isorhamnetin.
Methods.
Mouse models of hepatic fibrosis were established by intraperitoneal injection of carbon tetrachloride (CCl4) or bile duct ligation (BDL).
Isorhamnetin 10 or 30 mg/kg was administered by gavage 5 days per week for 8 weeks in the CCl4 model and for 2 weeks in the BDL model.
Protein and mRNA expressions were assayed by western blotting, immunohistochemistry, and quantitative real-time polymerase chain reaction.
Results.
Isorhamnetin significantly inhibited liver fibrosis in both models, inhibiting hepatic stellate cell (HSC) activation, extracellular matrix (ECM) deposition, and autophagy.
The effects were associated with downregulation of transforming growth factor β1 (TGF-β1) mediation of Smad3 and p38 mitogen-activated protein kinase (MAPK) signaling pathways.
Conclusion.
Isorhamnetin protected against liver fibrosis by reducing ECM formation and autophagy via inhibition of TGF-β1-mediated Smad3 and p38 MAPK signaling pathways.
American Psychological Association (APA)
Liu, Ning& Feng, Jiao& Lu, Xiya& Yao, Zhilu& Liu, Qing& Lv, Yang…[et al.]. 2019. Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1Smad3 and TGF-β1p38 MAPK Pathways. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193031
Modern Language Association (MLA)
Liu, Ning…[et al.]. Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1Smad3 and TGF-β1p38 MAPK Pathways. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193031
American Medical Association (AMA)
Liu, Ning& Feng, Jiao& Lu, Xiya& Yao, Zhilu& Liu, Qing& Lv, Yang…[et al.]. Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1Smad3 and TGF-β1p38 MAPK Pathways. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193031