Immune Regulation of RAW264.7 Cells In Vitro by Flavonoids from Astragalus complanatus via Activating the NF-κB Signalling Pathway
Joint Authors
Li, Yu
Feng, Shibin
Wang, Xichun
Wu, Jinjie
Li, Manman
Ding, Hongyan
Li, Jinchun
Hao, Ning
Zou, Suping
Meng, Tingting
Tao, Huanqing
Ming, Pengfei
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The current study aimed at investigating the effects of flavonoids from Astragalus complanatus (FAC) on the proliferation, the contents, and gene expression levels of cytokines, secretion of surface stimulating factors, cell cycle, and the expression level of the NF-κB signalling pathway in RAW264.7 cells.
Our results revealed that compared with control group, the contents of IL-6, IL-1β, TNF-α, and NO and the mRNA expression levels of IL-6, IL-1β, TNF-α, and iNOS in FAC-treated groups significantly increased (p<0.01).
Moreover, FAC induced macrophage activation to release the above-mentioned mediators partly involved in NF-κB/MAPK signalling pathways.
Therefore, FAC regulates immune function in RAW264.7 cells via activating the NF-κB signalling pathway.
FAC could be applicable for agriculture, drug research, and food industry as a potent immune-modulatory agent.
American Psychological Association (APA)
Li, Yu& Hao, Ning& Zou, Suping& Meng, Tingting& Tao, Huanqing& Ming, Pengfei…[et al.]. 2018. Immune Regulation of RAW264.7 Cells In Vitro by Flavonoids from Astragalus complanatus via Activating the NF-κB Signalling Pathway. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193047
Modern Language Association (MLA)
Li, Yu…[et al.]. Immune Regulation of RAW264.7 Cells In Vitro by Flavonoids from Astragalus complanatus via Activating the NF-κB Signalling Pathway. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193047
American Medical Association (AMA)
Li, Yu& Hao, Ning& Zou, Suping& Meng, Tingting& Tao, Huanqing& Ming, Pengfei…[et al.]. Immune Regulation of RAW264.7 Cells In Vitro by Flavonoids from Astragalus complanatus via Activating the NF-κB Signalling Pathway. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193047