Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model

Joint Authors

Sheikh, Nadeem
Azam, Fareeha
Ali, Gibran
Tayyeb, Asima

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-07-02

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Fagonia indica is a traditionally used phytomedicine to cure hepatic ailments.

However, efficient validation of its hepatoprotective effect and molecular mechanisms involved are not yet well established.

Therefore, the present study was designed to evaluate the hepatoprotective activity of Fagonia indica and to understand the molecular mechanisms involved in the reversal of hepatic injury.

The liver injury mouse model was established by thioacetamide followed by oral administration of plant extract.

Serum biochemical and histological analyses were performed to assess the level of hepatic injury.

Expression analysis of proinflammatory, hepatic, and immune regulatory genes was performed with RT-PCR.

Results of serological and histological analyses described the restoration of normal liver function and architecture in mice treated with plant extract.

In addition, altered expression of proinflammatory (IL-1β, IL-6, TNF-α, and TGF-β) and hepatic (krt-18 and albumin) markers further strengthens the liver injury reversal effects of Fagonia indica.

Furthermore, a significant expression regulation of innate immunity components such as toll-like receptors 4 and 9 and MyD-88 was observed suggesting an immune regulatory role of the plant in curing liver injury.

In conclusion, the current study not only proposes Fagonia indica, a strong hepatoprotective candidate, but also recommends an immune regulatory toll-like receptor pathway as an important therapeutic target in liver diseases.

American Psychological Association (APA)

Azam, Fareeha& Sheikh, Nadeem& Ali, Gibran& Tayyeb, Asima. 2018. Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193054

Modern Language Association (MLA)

Azam, Fareeha…[et al.]. Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193054

American Medical Association (AMA)

Azam, Fareeha& Sheikh, Nadeem& Ali, Gibran& Tayyeb, Asima. Fagonia indica Repairs Hepatic Damage through Expression Regulation of Toll-Like Receptors in a Liver Injury Model. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193054

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193054