Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke
Joint Authors
Li, Qiang
Feng, Hua
Chen, Yujie
Zhang, Le
Xiao, Ming
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death.
Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand.
Evoked by the concept of vascular neural network, the unveiled neural vascular mechanism gains more and more attentions.
Astrocyte, neuron, pericyte, endothelium, and so forth are formed as a communicate network to regulate with each other as well as the cerebral blood flow.
However, the signaling molecules responsible for this communication between these new players and blood vessels are yet to be definitively confirmed.
Recent evidence suggested the pivotal role of transcriptional mechanism, including but not limited to miRNA, lncRNA, exosome, and so forth, for the cerebral blood flow autoregulation.
In the present review, we sought to summarize the hemodynamic changes and underline neural vascular mechanism for cerebral blood flow autoregulation in stroke-prone state and after hemorrhagic stroke and hopefully provide more systematic and innovative research interests for the pathophysiology and therapeutic strategies of hemorrhagic stroke.
American Psychological Association (APA)
Xiao, Ming& Li, Qiang& Feng, Hua& Zhang, Le& Chen, Yujie. 2017. Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193063
Modern Language Association (MLA)
Xiao, Ming…[et al.]. Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193063
American Medical Association (AMA)
Xiao, Ming& Li, Qiang& Feng, Hua& Zhang, Le& Chen, Yujie. Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193063