Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis
Joint Authors
Nandakumar, Kutty Selva
Fang, Qinghua
Ou, Jiaxin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-27
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self-structures in the serum and synovial fluid.
These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have different characteristics, diagnostic/prognostic value, and pathological significance in RA patients.
Some of these antibodies are present in the patients’ serum several years before the onset of clinical disease.
Various genetic and environmental factors are associated with autoantibody production against different autoantigenic targets.
Both the activating and inhibitory FcγRs and the activation of different complement cascades contribute to the downstream effector functions in the antibody-mediated disease pathology.
Interplay between several molecules (cytokines, chemokines, proteases, and inflammatory mediators) culminates in causing damage to the articular cartilage and bones.
In addition, autoantibodies are proven to be useful disease markers for RA, and different diagnostic tools are being developed for early diagnosis of the clinical disease.
Recently, a direct link was proposed between the presence of autoantibodies and bone erosion as well as in the induction of pain.
In this review, the diagnostic value of autoantibodies, their synthesis and function as a mediator of joint inflammation, and the significance of IgG-Fc glycosylation are discussed.
American Psychological Association (APA)
Fang, Qinghua& Ou, Jiaxin& Nandakumar, Kutty Selva. 2019. Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1193067
Modern Language Association (MLA)
Fang, Qinghua…[et al.]. Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis. Mediators of Inflammation No. 2019 (2019), pp.1-22.
https://search.emarefa.net/detail/BIM-1193067
American Medical Association (AMA)
Fang, Qinghua& Ou, Jiaxin& Nandakumar, Kutty Selva. Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1193067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193067