Cytokines in Preterm Delivery: Proposal of a New Diagnostic Algorithm
Joint Authors
Raba, Grzegorz
Tabarkiewicz, Jacek
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Predicting preterm delivery within 7 days is very important for the proper timing of glucocorticosteroid administration.
If within 7 days after glucocorticosteroid administration, the delivery does not occur, it remains questionable if repeated glucocorticosteroid therapy results in improved infant respiratory function.
Therefore, differentiation of preterm delivery from false preterm delivery is clinically significant.
The aim of this study was to create a diagnostic algorithm to distinguish preterm delivery from false preterm delivery on the basis of concentrations of selected cytokines.
The study group (n=622) were patients hospitalized due to threatened preterm delivery.
To assess the concentration of cytokines in the serum, we used a multiplex method, which allows simultaneous determination of 13 cytokines.
The sets consist of the following cytokines: IGFBP-1, IGFBP-2, BDNF, L-Selectin, E-Selectin, ICAM-1, PECAM, VCAM-1, MIP-1d, MIP-3b, Eotaxin-1, Eotaxin-2, and BLC.
In the study group, 67.8% patients had preterm delivery and 32.2% had false preterm delivery.
Based on the analysis of cytokine concentrations, a classification tree to distinguish between preterm delivery and false preterm delivery was created.
Our findings show the possibility of prediction of preterm delivery with the use of a classification and regression tree of selected cytokine concentration.
American Psychological Association (APA)
Raba, Grzegorz& Tabarkiewicz, Jacek. 2018. Cytokines in Preterm Delivery: Proposal of a New Diagnostic Algorithm. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1193071
Modern Language Association (MLA)
Raba, Grzegorz& Tabarkiewicz, Jacek. Cytokines in Preterm Delivery: Proposal of a New Diagnostic Algorithm. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1193071
American Medical Association (AMA)
Raba, Grzegorz& Tabarkiewicz, Jacek. Cytokines in Preterm Delivery: Proposal of a New Diagnostic Algorithm. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1193071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193071