Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin
Joint Authors
Scharffetter-Kochanek, Karin
Ignatius, Anita
Messerer, David A. C.
Kovtun, A.
Huber-Lang, Markus S.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Following severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system.
Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequent repair processes.
However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst.
Alterations in neutrophil biology may contribute to trauma-associated complications, including immune suppression, sepsis, multiorgan dysfunction, and disturbed tissue regeneration.
Furthermore, there is evidence that neutrophil actions depend on the quality of the initial stimulus, including trauma localization and severity, the micromilieu in the affected tissue, and the patient’s overall inflammatory status.
In the present review, we describe the effects of severe trauma on the neutrophil phenotype and dysfunction and the consequences for tissue repair.
We particularly concentrate on the role of neutrophils in wound healing, lung injury, and bone fractures, because these are the most frequently affected tissues in severely injured patients.
American Psychological Association (APA)
Kovtun, A.& Messerer, David A. C.& Scharffetter-Kochanek, Karin& Huber-Lang, Markus S.& Ignatius, Anita. 2018. Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193079
Modern Language Association (MLA)
Kovtun, A.…[et al.]. Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193079
American Medical Association (AMA)
Kovtun, A.& Messerer, David A. C.& Scharffetter-Kochanek, Karin& Huber-Lang, Markus S.& Ignatius, Anita. Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193079