DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus

Joint Authors

Pacheco-Tena, Cesar Francisco
González-Chávez, Susana Aideé
Quiñonez-Flores, Celia María
Mireles-Canales, Martha Paola
León-López, Ever Adán

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-07-12

Country of Publication

Egypt

No. of Pages

18

Main Subjects

Biology

Abstract EN

Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood.

SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involved.

Recently, the description of novel genes conferring susceptibility to develop SLE even in their own (monogenic lupus) has raised the interest in DNA dynamics since many of these genes are linked to DNA repair.

Damage to DNA induces an inflammatory response and eventually triggers an immune response, including those targeting self-antigens.

We review the evidence that indicates that patients with SLE present higher levels of DNA damage than normal subjects do and that several proteins involved in the preservation of the genomic stability show polymorphisms, some of which increase the risk for SLE development.

Also, the experience from animal models reinforces the connection between DNA damage and defective repair in the development of SLE-like disease including characteristic features such as anti-DNA antibodies and nephritis.

Defining the role of DNA damage response in SLE pathogenesis might be strategic in the quest for novel therapies.

American Psychological Association (APA)

Mireles-Canales, Martha Paola& González-Chávez, Susana Aideé& Quiñonez-Flores, Celia María& León-López, Ever Adán& Pacheco-Tena, Cesar Francisco. 2018. DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1193086

Modern Language Association (MLA)

Mireles-Canales, Martha Paola…[et al.]. DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1193086

American Medical Association (AMA)

Mireles-Canales, Martha Paola& González-Chávez, Susana Aideé& Quiñonez-Flores, Celia María& León-López, Ever Adán& Pacheco-Tena, Cesar Francisco. DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1193086

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193086