Myokines as Possible Therapeutic Targets in Cancer Cachexia
Joint Authors
Bastian, Alexandra
Manole, Emilia
Dumitru, Carmen
Popescu, Bogdan Ovidiu
Ceafalan, Laura Cristina
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass.
This syndrome has a dramatic impact on the patient’s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival.
Despite this, cachexia is still underestimated and often untreated.
New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets.
The skeletal muscle can act as an endocrine organ.
Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes.
In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.
American Psychological Association (APA)
Manole, Emilia& Ceafalan, Laura Cristina& Popescu, Bogdan Ovidiu& Dumitru, Carmen& Bastian, Alexandra. 2018. Myokines as Possible Therapeutic Targets in Cancer Cachexia. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193087
Modern Language Association (MLA)
Manole, Emilia…[et al.]. Myokines as Possible Therapeutic Targets in Cancer Cachexia. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193087
American Medical Association (AMA)
Manole, Emilia& Ceafalan, Laura Cristina& Popescu, Bogdan Ovidiu& Dumitru, Carmen& Bastian, Alexandra. Myokines as Possible Therapeutic Targets in Cancer Cachexia. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193087