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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities
Joint Authors
Carubbi, Francesco
Cipriani, Paola
Giacomelli, Roberto
Ruscitti, Piero
Di Benedetto, Paola
Berardicurti, Onorina
Liakouli, Vasiliki
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rheumatoid arthritis is a chronic autoimmune disease affecting typically synovial joints and leading to progressive articular damage, disability, and reduced quality of life.
Despite better recent therapeutic strategies improving long-term outcomes, RA is associated with a high rate of comorbidities, infections, malignancies, and cardiovascular disease (CVD).
Remarkably, some well-known pathogenic proinflammatory mediators in RA, such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), may play a pivotal role in the development of CVD.
Interestingly, different preclinical and clinical studies have suggested that biologic agents commonly used to treat RA patients may be effective in improving CVD.
In this context, the contribution of adipocytokines has been suggested.
Adipocytokines are pleiotropic molecules, mainly released by white adipose tissue and immune cells.
Adipocytokines modulate the function of different tissues and cells, and in addition to energy homeostasis and metabolism, amplify inflammation, immune response, and tissue damage.
Adipocytokines may contribute to the proinflammatory state in RA patients and development of bone damage.
Furthermore, they could be associated with the occurrence of CVD.
In this study, we reviewed available evidence about adipocytokines in RA, because of their involvement in disease activity, associated CVD, and possible biomarkers of prognosis and treatment outcome and because of their potential as a possible new therapeutic target.
American Psychological Association (APA)
Ruscitti, Piero& Di Benedetto, Paola& Berardicurti, Onorina& Liakouli, Vasiliki& Carubbi, Francesco& Cipriani, Paola…[et al.]. 2018. Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193102
Modern Language Association (MLA)
Ruscitti, Piero…[et al.]. Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1193102
American Medical Association (AMA)
Ruscitti, Piero& Di Benedetto, Paola& Berardicurti, Onorina& Liakouli, Vasiliki& Carubbi, Francesco& Cipriani, Paola…[et al.]. Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193102