Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis
Joint Authors
Chen, Weiqian
Lin, Jin
Ke, Yini
Wang, Qin
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the presence of autoantibodies against citrullinated protein antigens and proinflammatory cytokines which cause chronic synovitis, bone erosion, and eventual deformity; however, the precise etiology of RA is unclear.
In the early stage of RA, neutrophils migrate into the articular cavity, become activated, and exert their function in an inflammatory process, suggesting an essential role of neutrophils in the initial events contributing to the pathogenesis of RA.
Solid evidence exists that supports the contribution of neutrophil extracellular traps (NETs) to the production of autoantibodies against citrullinated proteins which can trigger the immune reaction in RA.
Concurrently, proinflammatory cytokines regulate the neutrophil migration, apoptosis, and NET formation.
As a result, the inflammatory neutrophils produce more cytokines and influence other immune cells thereby perpetuating the inflammatory condition in RA.
In this review, we summarize the advances made in improving our understanding of neutrophil migration, apoptosis, and NET formation in the presence of an RA inflammatory milieu.
We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.
American Psychological Association (APA)
Chen, Weiqian& Wang, Qin& Ke, Yini& Lin, Jin. 2018. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193131
Modern Language Association (MLA)
Chen, Weiqian…[et al.]. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193131
American Medical Association (AMA)
Chen, Weiqian& Wang, Qin& Ke, Yini& Lin, Jin. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193131