Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

Joint Authors

Chen, Weiqian
Lin, Jin
Ke, Yini
Wang, Qin

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-12-03

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the presence of autoantibodies against citrullinated protein antigens and proinflammatory cytokines which cause chronic synovitis, bone erosion, and eventual deformity; however, the precise etiology of RA is unclear.

In the early stage of RA, neutrophils migrate into the articular cavity, become activated, and exert their function in an inflammatory process, suggesting an essential role of neutrophils in the initial events contributing to the pathogenesis of RA.

Solid evidence exists that supports the contribution of neutrophil extracellular traps (NETs) to the production of autoantibodies against citrullinated proteins which can trigger the immune reaction in RA.

Concurrently, proinflammatory cytokines regulate the neutrophil migration, apoptosis, and NET formation.

As a result, the inflammatory neutrophils produce more cytokines and influence other immune cells thereby perpetuating the inflammatory condition in RA.

In this review, we summarize the advances made in improving our understanding of neutrophil migration, apoptosis, and NET formation in the presence of an RA inflammatory milieu.

We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.

American Psychological Association (APA)

Chen, Weiqian& Wang, Qin& Ke, Yini& Lin, Jin. 2018. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193131

Modern Language Association (MLA)

Chen, Weiqian…[et al.]. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193131

American Medical Association (AMA)

Chen, Weiqian& Wang, Qin& Ke, Yini& Lin, Jin. Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193131

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193131