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Regulation of Immune Cell Functions by Metabolic Reprogramming
Author
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recent findings show that the metabolic status of immune cells can determine immune responses.
Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer.
The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions.
In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticity of the immune cells and responsible for the progression and regression of many pathological processes, notably cancer.
It is possible that metabolic changes in the microenvironment induced by other cellular components are responsible for the functional plasticity of immune cells.
This review explores the molecular mechanisms responsible for metabolic reprogramming in macrophages and T cells and also provides a summary of recent updates with regard to the functional modulation of the immune cells by metabolic changes in the microenvironment, notably the tumor microenvironment.
American Psychological Association (APA)
Kim, Jaehong. 2018. Regulation of Immune Cell Functions by Metabolic Reprogramming. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193136
Modern Language Association (MLA)
Kim, Jaehong. Regulation of Immune Cell Functions by Metabolic Reprogramming. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193136
American Medical Association (AMA)
Kim, Jaehong. Regulation of Immune Cell Functions by Metabolic Reprogramming. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193136