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Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability
Joint Authors
Wei, Sheng
Wang, Yang
Sun, Peng
Wei, Xia
Wu, Jibiao
Song, Chunhong
Qiao, Mingqi
Wang, Fushun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Premenstrual syndrome (PMS) refers to several physical and mental symptoms (such as irritability) commonly encountered in clinical gynaecology.
The incidence of PMS has been increasing, attracting greater attention from medical fields.
However, PMS pathogenesis remains unclear.
This study employed two-dimensional gel electrophoresis (2DE) for proteomic map analysis of the hypothalamus and hippocampus of rat models of premenstrual syndrome (PMS) irritability.
Matrix-assisted laser desorption/ionisation time of flight mass spectroscopy (MALDI-TOF-MS) was used to identify proteins possibly related with PMS irritability.
Baixiangdan, a traditional Chinese medicine effective against PMS irritability, was used in the rat model to study putative target proteins of this medicine.
The hypothalamus and hippocampus of each group modelling PMS displayed the following features: decreased expression of Ulip2, tubulin beta chain 15, α actin, and interleukin 1 receptor accessory protein; increased expression of kappa-B motif-binding phosphoprotein; decreased expression of hydrolase at the end of ubiquitin carboxy, albumin, and aldolase protein; and increased expression of M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, and calcium-binding protein.
Contrasting with previous studies, the current study identified new proteins related to PMS irritability.
Our findings contribute to understanding the pathogenesis of PMS irritability and could provide a reference point for further studies.
American Psychological Association (APA)
Qiao, Mingqi& Sun, Peng& Wang, Yang& Wei, Sheng& Wei, Xia& Song, Chunhong…[et al.]. 2017. Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability. Neural Plasticity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193153
Modern Language Association (MLA)
Qiao, Mingqi…[et al.]. Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability. Neural Plasticity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1193153
American Medical Association (AMA)
Qiao, Mingqi& Sun, Peng& Wang, Yang& Wei, Sheng& Wei, Xia& Song, Chunhong…[et al.]. Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193153