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NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs
Joint Authors
Zhang, Xin
Hong, Siting
Qi, Shuhan
Liu, Wenxiu
Zhang, Xiaohui
Shi, Zhiyu
Chen, Wenjia
Zhao, Meng
Yin, Xinhua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Increasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases.
However, its role and activation mechanism during hypertension remains unclear.
In this study, we tested the role and mechanism of calcium-sensing receptor (CaSR) in NLRP3 inflammasome activation during hypertension.
We observed that the expressions of CaSR and NLRP3 were increased in spontaneous hypertensive rats (SHRs) along with aortic fibrosis.
In vascular smooth muscle cells (VSMCs), the activation of NLRP3 inflammasome associated with CaSR and collagen synthesis was induced by angiotensin II (Ang II).
Furthermore, inhibition of CaSR and NLRP3 inflammasome attenuated proinflammatory cytokine release, suggesting that CaSR-mediated activation of the NLRP3 inflammasome may be a therapeutic target in aortic dysfunction and vascular inflammatory lesions.
American Psychological Association (APA)
Zhang, Xin& Hong, Siting& Qi, Shuhan& Liu, Wenxiu& Zhang, Xiaohui& Shi, Zhiyu…[et al.]. 2019. NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1193170
Modern Language Association (MLA)
Zhang, Xin…[et al.]. NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1193170
American Medical Association (AMA)
Zhang, Xin& Hong, Siting& Qi, Shuhan& Liu, Wenxiu& Zhang, Xiaohui& Shi, Zhiyu…[et al.]. NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1193170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193170