Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats
Joint Authors
Henrich-Noack, Petra
Chamoun, Mira
Sergeeva, Elena G.
Jia, Shaobo
Grigartzik, Lisa
Ma, Jing
You, Qing
Huppé-Gourgues, Frédéric
Sabel, Bernhard A.
Vaucher, Elvire
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment.
Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration.
To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats.
Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals.
The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush.
Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity.
This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.
American Psychological Association (APA)
Chamoun, Mira& Sergeeva, Elena G.& Henrich-Noack, Petra& Jia, Shaobo& Grigartzik, Lisa& Ma, Jing…[et al.]. 2017. Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats. Neural Plasticity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193186
Modern Language Association (MLA)
Chamoun, Mira…[et al.]. Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats. Neural Plasticity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1193186
American Medical Association (AMA)
Chamoun, Mira& Sergeeva, Elena G.& Henrich-Noack, Petra& Jia, Shaobo& Grigartzik, Lisa& Ma, Jing…[et al.]. Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1193186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193186