Nicotinamide Administration Improves Remyelination after Stroke
Joint Authors
Wang, Cong-Xiao
Qian, Cheng
Zhang, Yi
Ding, Jie
Zhao, Zhen
Luan, Ying
Teng, Gao-jun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aims.
Stroke is a leading cause of morbidity and mortality.
This study aimed to determine whether nicotinamide administration could improve remyelination after stroke and reveal the underlying mechanism.
Methods.
Adult male C57BL/6J mice were intraperitoneally (i.p.) administered with nicotinamide (200 mg/kg, daily) or saline after stroke induced by photothrombotic occlusion of the middle cerebral artery.
FK866 (3 mg/kg, daily, bis in die), an inhibitor of NAMPT, and ANA-12 (0.5 mg/kg, daily), an antagonist of tropomyosin-related kinase B (TrkB), were administered intraperitoneally 1 h before nicotinamide administration.
Functional recovery, MRI, and histological assessment were performed after stroke at different time points.
Results.
The nicotinamide-treated mice showed significantly lower infarct area 7 d after stroke induction and significantly higher fractional anisotropy (FA) in the ipsilesional internal capsule (IC) 14 d after stroke induction than the other groups.
Higher levels of NAD+, BDNF, and remyelination markers were observed in the nicotinamide-treated group.
FK866 administration reduced NAD+ and BDNF levels in the nicotinamide-treated group.
ANA-12 administration impaired the recovery from stroke with no effect on NAD+ and BDNF levels.
Furthermore, lesser functional deficits were observed in the nicotinamide-treated group than in the control group.
Conclusions.
Nicotinamide administration improves remyelination after stroke via the NAD+/BDNF/TrkB pathway.
American Psychological Association (APA)
Wang, Cong-Xiao& Zhang, Yi& Ding, Jie& Zhao, Zhen& Qian, Cheng& Luan, Ying…[et al.]. 2017. Nicotinamide Administration Improves Remyelination after Stroke. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193195
Modern Language Association (MLA)
Wang, Cong-Xiao…[et al.]. Nicotinamide Administration Improves Remyelination after Stroke. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193195
American Medical Association (AMA)
Wang, Cong-Xiao& Zhang, Yi& Ding, Jie& Zhao, Zhen& Qian, Cheng& Luan, Ying…[et al.]. Nicotinamide Administration Improves Remyelination after Stroke. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193195