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Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease
Joint Authors
Chen, Jian-Jiao
Zhao, Jie
Li, Shao
Zhao, Bin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Exosomes are bilipid layer-enclosed vesicles derived from endosomes and are released from neural cells.
They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) that are delivered to neighboring cells and/or are transported to distant sites.
miRNAs released from exosomes appear to be associated with multiple neurodegenerative conditions linking to Alzheimer’s disease (AD) which is marked by hyperphosphorylated tau proteins and accumulation of Aβ plaques.
Exciting findings reveal that miRNAs released from exosomes modulate the expression and function of amyloid precursor proteins (APP) and tau proteins.
These open up the possibility that dysfunctional exosomal miRNAs may influence AD progression.
In addition, it has been confirmed that the interaction between miRNAs released by exosomes and Toll-like receptors (TLR) initiates inflammation.
In exosome support-deprived neurons, exosomal miRNAs may regulate neuroplasticity to relieve neurological damage.
In this review, we summarize the literature on the function of exosomal miRNAs in AD pathology, the potential of these miRNAs as diagnostic biomarkers in AD, and the use of exosomes in the delivery of miRNAs which may lead to major advances in the field of macromolecular drug delivery.
American Psychological Association (APA)
Chen, Jian-Jiao& Zhao, Bin& Zhao, Jie& Li, Shao. 2017. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193201
Modern Language Association (MLA)
Chen, Jian-Jiao…[et al.]. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193201
American Medical Association (AMA)
Chen, Jian-Jiao& Zhao, Bin& Zhao, Jie& Li, Shao. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193201