Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease

Joint Authors

Chen, Jian-Jiao
Zhao, Jie
Li, Shao
Zhao, Bin

Source

Neural Plasticity

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-07-09

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology
Medicine

Abstract EN

Exosomes are bilipid layer-enclosed vesicles derived from endosomes and are released from neural cells.

They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) that are delivered to neighboring cells and/or are transported to distant sites.

miRNAs released from exosomes appear to be associated with multiple neurodegenerative conditions linking to Alzheimer’s disease (AD) which is marked by hyperphosphorylated tau proteins and accumulation of Aβ plaques.

Exciting findings reveal that miRNAs released from exosomes modulate the expression and function of amyloid precursor proteins (APP) and tau proteins.

These open up the possibility that dysfunctional exosomal miRNAs may influence AD progression.

In addition, it has been confirmed that the interaction between miRNAs released by exosomes and Toll-like receptors (TLR) initiates inflammation.

In exosome support-deprived neurons, exosomal miRNAs may regulate neuroplasticity to relieve neurological damage.

In this review, we summarize the literature on the function of exosomal miRNAs in AD pathology, the potential of these miRNAs as diagnostic biomarkers in AD, and the use of exosomes in the delivery of miRNAs which may lead to major advances in the field of macromolecular drug delivery.

American Psychological Association (APA)

Chen, Jian-Jiao& Zhao, Bin& Zhao, Jie& Li, Shao. 2017. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193201

Modern Language Association (MLA)

Chen, Jian-Jiao…[et al.]. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193201

American Medical Association (AMA)

Chen, Jian-Jiao& Zhao, Bin& Zhao, Jie& Li, Shao. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193201

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1193201