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Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats
Joint Authors
Zeng, Yuanshan
Zhang, Yu-Ting
Jin, Hui
Wang, Jun-Hua
Wen, Lan-Yu
Yang, Yang
Ruan, Jing-Wen
Zhang, Shu-Xin
Ling, Eng-Ang
Ding, Ying
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern.
Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy.
Tail nerve electrical stimulation (TANES) has been shown to activate the central pattern generator (CPG) and improve the locomotion recovery of spinal contused rats.
Electroacupuncture (EA) is a traditional Chinese medical practice which has been proven to have a neural protective effect.
Here, we examined the effects of TANES and EA on lumbar motor neurons and hindlimb muscle in spinal transected rats, respectively.
From the third day postsurgery, rats in the TANES group were treated 5 times a week and those in the EA group were treated once every other day.
Four weeks later, both TANES and EA showed a significant impact in promoting survival of lumbar motor neurons and expression of choline acetyltransferase (ChAT) and ameliorating atrophy of hindlimb muscle after SCI.
Meanwhile, the expression of neurotrophin-3 (NT-3) in the same spinal cord segment was significantly increased.
These findings suggest that TANES and EA can augment the expression of NT-3 in the lumbar spinal cord that appears to protect the motor neurons as well as alleviate muscle atrophy.
American Psychological Association (APA)
Zhang, Yu-Ting& Jin, Hui& Wang, Jun-Hua& Wen, Lan-Yu& Yang, Yang& Ruan, Jing-Wen…[et al.]. 2017. Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193218
Modern Language Association (MLA)
Zhang, Yu-Ting…[et al.]. Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193218
American Medical Association (AMA)
Zhang, Yu-Ting& Jin, Hui& Wang, Jun-Hua& Wen, Lan-Yu& Yang, Yang& Ruan, Jing-Wen…[et al.]. Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193218