Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2
Joint Authors
Ke, Bin
Wei, Ting
Huang, Yuanyuan
Gong, Yuxin
Wu, Gang
Liu, Junfang
Chen, Xiaoting
Shi, Lin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Treatment with cisplatin (DDP) is one of the standard therapies used to treat non-small-cell lung cancer (NSCLC) and fundamentally causes resistance in cancer cells, which eventually poses as an obstacle to the efficacy of chemotherapy in NSCLC.
Efforts are on all over the world to explore a sensitizer of NSCLC to DDP.
Here, we studied the effect of IL-7 on the resistance of NSCLC to chemotherapy.
We observed that IL-7 treatment significantly enhanced DDP-induced effects in A549 and A549/DDP cells (DDP-resistant cells), including decreased cell viability and proliferation, as well as increased cell apoptosis and S arrest, indicating that IL-7 treatment resensitized DDP-resistant NSCLC cells to DDP.
Subsequently, IL-7 enhanced the sensitivity of PI3K/AKT signaling and expressions of ABCG2 to DDP.
By inhibiting IL-7 signaling via IL-7R knockdown or activating PI3K/AKT signaling via PI3K activation, the resensitization to DDP by IL-7 was abrogated, and the expression levels of ABCG2, p-PI3K, and p-AKT were found to be significantly higher.
In vivo results also confirmed that IL-7 only in combination with DDP could remarkably induce tumor regression with reduced levels of ABCG2 in tumorous tissues.
These findings indicate that IL-7, apart from its adjuvant effect, could overcome multidrug resistance of DDP to restore its chemotherapy sensitivity.
American Psychological Association (APA)
Ke, Bin& Wei, Ting& Huang, Yuanyuan& Gong, Yuxin& Wu, Gang& Liu, Junfang…[et al.]. 2019. Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1193237
Modern Language Association (MLA)
Ke, Bin…[et al.]. Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2. Mediators of Inflammation No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1193237
American Medical Association (AMA)
Ke, Bin& Wei, Ting& Huang, Yuanyuan& Gong, Yuxin& Wu, Gang& Liu, Junfang…[et al.]. Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1193237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193237