Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β
Joint Authors
Zhang, Jifeng
Tan, Minghui
Yin, Yichen
Guo, Guoqing
Ji, Zhisheng
Cai, Zhenbin
Zhao, Bo
Li, Jiong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Amyloid-β (Aβ) plays an important role in Alzheimer’s disease (AD), as oligomeric Aβ induces loss of postsynaptic AMPA receptors (AMPARs) leading to cognitive deficits.
The loss of postsynaptic AMPARs is mediated through the clathrin-dependent endocytosis pathway, in which endophilin2 is one of the important regulatory proteins.
Endophilin2, which is enriched in both the pre- and postsynaptic membrane, has previously been reported to be important for recycling of synaptic vesicles at the presynaptic membrane.
However, the role of endophilin2 in oligomeric Aβ-induced postsynaptic AMPAR endocytosis is not well understood.
In this study, we show that endophilin2 does not affect constitutive AMPAR endocytosis.
Endophilin2 knockdown, but not overexpression, resisted oligomeric Aβ-induced AMPAR dysfunction.
Moreover, endophilin2 colocalized and interacted with GluA1, a subunit of AMPAR, to regulate oligomeric Aβ-induced AMPAR endocytosis.
Thus, we have determined a role of endophilin2 in oligomeric Aβ-induced postsynaptic AMPAR dysfunction, indicating possible directions for preventing the loss of AMPARs in cognitive impairment and providing evidence for the clinical treatment of AD.
American Psychological Association (APA)
Zhang, Jifeng& Yin, Yichen& Ji, Zhisheng& Cai, Zhenbin& Zhao, Bo& Li, Jiong…[et al.]. 2017. Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193248
Modern Language Association (MLA)
Zhang, Jifeng…[et al.]. Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193248
American Medical Association (AMA)
Zhang, Jifeng& Yin, Yichen& Ji, Zhisheng& Cai, Zhenbin& Zhao, Bo& Li, Jiong…[et al.]. Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193248