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Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study
Joint Authors
Murphy, B.
Yielder, Paul
Gourgouvelis, Joanne
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Memory impairments are a frequently reported cognitive symptom in people suffering from major depressive disorder (MDD) and often persist despite antidepressant therapy.
Neuroimaging studies have identified abnormal hippocampal activity during memory processes in MDD.
Exercise as an ad-on treatment for MDD is a promising therapeutic strategy shown to improve mood, cognitive function, and neural structure and function.
To advance our understanding of how exercise impacts neural function in MDD, we must also understand how exercise impacts healthy individuals without MDD.
This pilot study used a subsequent memory paradigm to investigate the effects of an eight-week exercise intervention on hippocampal function in low-active healthy (n=8) and low-active MDD (n=8) individuals.
Results showed a marked improvement in depression scores for the MDD group (p<0.0001) and no change in memory performance for either group (p>0.05).
Functional imaging results showed a marginally significant decrease in hippocampal activity in both groups following the exercise intervention.
Our whole brain analysis collapsed across groups revealed a similar deactivation pattern across several memory-associated regions.
These results suggest that exercise may enhance neural efficiency in low-fit individuals while still resulting in a substantially greater mood effect for those suffering from MDD.
This trial is registered with clinical trials.gov NCT03191994.
American Psychological Association (APA)
Gourgouvelis, Joanne& Yielder, Paul& Murphy, B.. 2017. Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study. Neural Plasticity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193257
Modern Language Association (MLA)
Gourgouvelis, Joanne…[et al.]. Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study. Neural Plasticity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193257
American Medical Association (AMA)
Gourgouvelis, Joanne& Yielder, Paul& Murphy, B.. Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193257