Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis
Joint Authors
Mănuc, Mircea
Milanesi, Elena
Manuc, Teodora Ecaterina
Becheanu, Gabriel
Dobre, Maria
Arsene, Dorel Eugen
Ţieranu, Cristian George
Maj, Carlo
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci.
Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn’s disease (CD).
Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD.
The aim of our study was to identify gene expression profiles specific for UC and CD, in endoscopically affected and normal intestinal colonic mucosa from IBD patients.
We evaluated a panel of 84 genes related to the IBD-inflammatory pathway on 21 UC and 22 CD paired inflamed and not inflamed mucosa and on age-matched normal mucosa from 21 non-IBD controls.
Two genes in UC (CCL11 and MMP10) and two in CD (C4BPB and IL1RN) showed an upregulation trend in both noninflamed and inflamed mucosa compared to controls.
Our results suggest that the transcript levels of CCL11, MMP10, C4BPB, and IL1RN are candidate biomarkers that could help in clinical practice for the differential diagnosis between UC and CD and could guide new research on future therapeutic targets.
American Psychological Association (APA)
Dobre, Maria& Milanesi, Elena& Manuc, Teodora Ecaterina& Arsene, Dorel Eugen& Ţieranu, Cristian George& Maj, Carlo…[et al.]. 2018. Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193263
Modern Language Association (MLA)
Dobre, Maria…[et al.]. Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1193263
American Medical Association (AMA)
Dobre, Maria& Milanesi, Elena& Manuc, Teodora Ecaterina& Arsene, Dorel Eugen& Ţieranu, Cristian George& Maj, Carlo…[et al.]. Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193263